PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
نویسندگان
چکیده
منابع مشابه
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's functions are mostly studied separately, and reports on their mutual crosstalk are scarce. Here, we identify PLK1 as a physical MTORC1 ...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2017
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2016.1263781